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Journal of Clinical Pathology. An early historical survey”.
Blood tests on patients with OFC generally show high levels of calcium normal levels are considered to range between 8. This page was last edited on 14 Octoberat In especially severe cases of OFC, parathyroidectomy, or the full removal of the parathyroid glands, is the chosen route of treatment.
Approximately 1 in 10 documented cases of hyperparathyroidism are a result of hereditary factors. National Library of Medicine. Osteitis fibrosa cystica is the result of unchecked hyperparathyroidism, or the overactivity of the parathyroid glandswhich results in an overproduction of parathyroid hormone PTH. Major mutations which can lead to hyperparathyroidism generally involve the parathyroid hormone receptor, G proteinsor adenylate cyclase.
The hyperparathyroidism can be triggered by a parathyroid adenomahereditary factors, parathyroid carcinomaor renal osteodystrophy. Parathyroidectomy has been shown to result in the reversal of bone resorption and the complete regression of brown tumors. The addition of weight loss, appetite lossvomiting, polyuriaand polydipsia to the aforementioned symptoms may indicate that OFC is the result of parathyroid carcinoma. Parathyroid carcinoma cancer of the parathyroid gland is the rarest cause of OFC, accounting for about 0.
The major symptoms of OFC are bone pain or tenderness, bone fracturesand skeletal deformities such as bowing of the bones. Hypofunction Diabetes mellitus types: Disorders such as familial hyperparathyroidism, multiple endocrine neoplasia type 1 MEN Type 1 and hyperparathyroidism-jaw tumor syndrome can, if left unchecked, result in OFC.
A case report and review of the literature”. British Journal of Surgery. Proceedings of the National Academy of Sciences. Infobox medical condition All articles with unsourced statements Articles with unsourced statements from November Good articles.
Osteitis fibrosa cystica – Wikipedia
The discovery and subsequent description of the parathyroid glands is credited to Ivar Sandstrom, goitter his publication, On a New Gland in Man and Several Mammals-Glandulae Parathyroideaereceived little goiger. Osteitis fibrosis cystica, abbreviated OFC, also known as osteitis fibrosaosteodystrophia fibrosaand von Recklinghausen’s disease of bone not to be confused with von Recklinghausen’s disease, neurofibromatosis type Iis caused by hyperparathyroidismwhich is a surplus of parathyroid hormone from over-active parathyroid glands.
Thus, excess PTH in hyperparathyroidism causes elevated blood calcium levels, or hypercalcemia. Views Read Edit View history. From Wikipedia, the free encyclopedia.
Hyperthyroxinemia Thyroid hormone resistance Familial dysalbuminemic hyperthyroxinemia Hashitoxicosis Thyrotoxicosis factitia Graves’ disease Thyroid storm. Archived PDF from the original on First described in the nineteenth century, Ggoiter is currently detected through a combination of blood testingX-raysand tissue sampling.
The effects of OFC on bone are largely dependent on the duration of the disease and the level of parathyroid hormone PTH produced. Canadian Medical Association Journal. Osteitis fibrosa cystica Brown tumor. Annals of the Royal College of Surgeons of England. Thirty percent of patients with OFC-like tumors caused by metastatic parathyroid carcinoma who undergo surgery see a local recurrence of symptoms.
The patient’s symptoms disappeared, only to return in approximately six years as a result of renal stones that were diagnosed only after the patient had died.
OFC is a common presentation of renal osteodystrophywhich is a term used to gioter to the skeletal complications of end stage renal disease ESRD. Additionally, patients with OFC who have undergone parathyroidectomy begin to show regression of brown tumors within six months.